Poster 1013: IL-4R alpha antibody inhibits IgE production and airway remodeling in mouse model of house dust mite-induced eosinophilic asthma
نویسندگان
چکیده
Background Allergic asthma is associated with T helper 2 (Th2) immune response to an allergen. IL-4 and IL-13, key cytokines involved in Th2 immunity, promote eosinophilic inflammation and B cell isotype switching to IgE. House Dust Mite (HDM) allergen has been shown to induce allergic asthma in a mouse model via Th2 immune response that drives eosinophilia and influx of effector T cells into lung. An IL-4Raplha antibody that blocks signaling of IL-4 and IL-13 through both Type I (IL-4Ralpha/ IL-2Rgamma) and Type II (IL-4Ralpha/IL-13R) receptors, and an IL-13Ra2-Fc fusion protein that prevents binding and signaling of IL-13 via Type II receptor, were both tested in the HDM-induced mouse model of asthma.
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